A brief glimpse into the past

Team, Place & City Details

King's Lynn F.C.

King's Lynn Football Club was an English association football club based in King's Lynn, Norfolk. The club was founded in 1879 and they were wound up at the High Court on 25 November 2009 with debts of £77,000, going out of business in December after a failed appeal.

King's Lynn Stars

King's Lynn Stars are a motorcycle speedway team who compete in the SGB Premiership. The nickname "Stars" comes from the defunct Norwich Stars team.

King's Lynn Fury

King's Lynn Fury is an amateur basketball team from King's Lynn, Norfolk, competing in the National Basketball League. The club was established in 2003 by James Bamfield.

King's Lynn Town F.C.
King's Lynn Town F.C.

King's Lynn Town Football Club is a football club based in King's Lynn, Norfolk, England. They are currently members of the Southern League Premier Division Central and play at the Walks.

Histone
Histone

In biology, histones are highly alkaline proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes. They are the chief protein components of chromatin, acting as spools around which DNA winds, and playing a role in gene regulation.

Histone deacetylase
Histone deacetylase

Histone deacetylases are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation.

Histone deacetylase inhibitor

Histone deacetylase inhibitors are chemical compounds that inhibit histone deacetylases. HDIs have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptics.

Histone acetylation and deacetylation
Histone acetylation and deacetylation

Histone acetylation and deacetylation are the processes by which the lysine residues within the N-terminal tail protruding from the histone core of the nucleosome are acetylated and deacetylated as part of gene regulation. Histone acetylation and deacetylation are essential parts of gene regulation.

Histone acetyltransferase
Histone acetyltransferase

Histone acetyltransferases are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off.

Histone methyltransferase
Histone methyltransferase

Histone methyltransferases are histone-modifying enzymes (e.g., histone-lysine N-methyltransferases and histone-arginine N-methyltransferases), that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.

Histone octamer

A histone octamer is the eight protein complex found at the center of a nucleosome core particle. It consists of two copies of each of the four core histone proteins .

Histon and Impington
Histon and Impington

Histon and Impington are villages in the county of Cambridgeshire, England. They are situated just north of Cambridge with the main bulk of the settlements being separated from the city by the A14 road .

Histone methylation

Histone methylation is a process by which methyl groups are transferred to amino acids of histone proteins that make up nucleosomes, which the DNA double helix wraps around to form chromosomes. Methylation of histones can either increase or decrease transcription of genes, depending on which amino acids in the histones are methylated, and how many methyl groups are attached.